Biochemistry: Chemical Biology

Offered by: Biochemistry     Degree: Doctor of Philosophy

Program Requirements

Thesis

A thesis for the doctoral degree must constitute original scholarship and must be a distinct contribution to knowledge. It must show familiarity with previous work in the field and must demonstrate ability to plan and carry out research, organize results, and defend the approach and conclusions in a scholarly manner. The research presented must meet current standards of the discipline; as well, the thesis must clearly demonstrate how the research advances knowledge in the field. Finally, the thesis must be written in compliance with norms for academic and scholarly expression and for publication in the public domain.

Required Courses (7 credits)

• BIOC 610 Seminars in Chemical Biology 1 (1 credit)

  Offered by: Biochemistry (Faculty of Medicine and Health Sciences)

  Administered by: Graduate Studies

  Overview

  Biochemistry : First multidisciplinary seminar in chemical biology.

  Terms: This course is not scheduled for the 2022-2023 academic year.

  Instructors: There are no professors associated with this course for the 2022-2023 academic year.

  • Restrictions: Open only to students registered for the M.Sc. or Ph.D. Graduate Option in Chemical Biology.

• BIOC 611 Seminars in Chemical Biology 3 (1 credit)

  Offered by: Biochemistry (Faculty of Medicine and Health Sciences)

  Administered by: Graduate Studies

  Overview

  Biochemistry : Third multidisciplinary seminar in chemical biology.

  Terms: This course is not scheduled for the 2022-2023 academic year.

  Instructors: There are no professors associated with this course for the 2022-2023 academic year.

  • Restrictions: Open only to students registered for the M.Sc. or Ph.D. Graduate Option in Chemical Biology.

• BIOC 689 Seminars in Chemical Biology 2 (1 credit)

  Offered by: Biochemistry (Faculty of Medicine and Health Sciences)

  Administered by: Graduate Studies

  Overview

  Biochemistry : Second multidisciplinary seminar in chemical biology.

  Terms: This course is not scheduled for the 2022-2023 academic year.

  Instructors: There are no professors associated with this course for the 2022-2023 academic year.

  • Restrictions: Open only to students registered for the M.Sc. or Ph.D. Graduate Option in Chemical Biology. Not open to students who have taken CHEM 689.

• BIOC 690 Seminars in Chemical Biology 4 (1 credit)

  Offered by: Biochemistry (Faculty of Medicine and Health Sciences)

  Administered by: Graduate Studies

  Overview

  Biochemistry : Fourth multidisciplinary seminar in chemical biology.

  Terms: This course is not scheduled for the 2022-2023 academic year.

  Instructors: There are no professors associated with this course for the 2022-2023 academic year.

  • Restrictions: Open only to students registered for the M.Sc. or Ph.D. Graduate Option in Chemical Biology. Not open to students who have taken CHEM 690.

• BIOC 696 Seminars in Biochemistry (3 credits) *

  Offered by: Biochemistry (Faculty of Medicine and Health Sciences)

  Administered by: Graduate Studies

  Overview

  Biochemistry : Seminars in biochemistry.

  Terms: Fall 2022, Winter 2023

  Instructors: Laberge, Christine E (Fall) Laberge, Christine E (Winter)

  • Restriction: Open to M.Sc. and Ph.D. Biochemistry students only.

• BIOC 701 Research Seminar 1 **

  Offered by: Biochemistry (Faculty of Medicine and Health Sciences)

  Administered by: Graduate Studies

  Overview

  Biochemistry : Presentation on original current laboratory research carried out by student.

  Terms: Fall 2022, Winter 2023

  Instructors: There are no professors associated with this course for the 2022-2023 academic year.

  • Biochemistry graduate students

• BIOC 702 Ph.D. Thesis Proposal **

  Offered by: Biochemistry (Faculty of Medicine and Health Sciences)

  Administered by: Graduate Studies

  Overview

  Biochemistry : Dissertation presented to Committee.

  Terms: Fall 2022, Winter 2023

  Instructors: There are no professors associated with this course for the 2022-2023 academic year.

  • Biochemistry graduate students

• BIOC 703 Ph.D. Seminar **

  Offered by: Biochemistry (Faculty of Medicine and Health Sciences)

  Administered by: Graduate Studies

  Overview

  Biochemistry : Presentation of the planned thesis including central findings and original contribution to knowledge in the field of research.

  Terms: Fall 2022, Winter 2023

  Instructors: There are no professors associated with this course for the 2022-2023 academic year.

  • Restriction: Ph.D. students in Biochemistry

* Students promoted directly from the M.Sc. to the Ph.D. program, and who registered for and passed BIOC 696 at the M.Sc. level, do not register for BIOC 696 at the Ph.D. level.

** NOTE: Students DO NOT register for these courses until notified by the Student Affairs Officer.

Students must complete BIOC 701 in the third term after admission to the program, BIOC 702 in the fifth or sixth term, and BIOC 703 approximately six months prior to submission of the Ph.D. thesis.

Complementary Courses*** (9 credits)

At least 3 credits from the following:

• CHEM 502 Advanced Bio-Organic Chemistry (3 credits)

  Offered by: Chemistry (Faculty of Science)

  Overview

  Chemistry : This course will cover biologically relevant molecules, particularly nucleic acids, proteins, and their building blocks. In each case, synthesis and biological functions will be discussed. The topics include synthesis of oligonucleotides and peptides; chemistry of phosphates; enzyme structure and function; coenzymes, and enzyme catalysis; polyketides; antiviral and anticancer agents.

  Terms: Winter 2023

  Instructors: Thibodeaux, Christopher; Luedtke, Nathan (Winter)

  • Winter

  • Prerequisite: CHEM 302

  • Restriction: Not open to students who have taken CHEM 402.

• CHEM 503 Drug Discovery (3 credits)

  Offered by: Chemistry (Faculty of Science)

  Overview

  Chemistry : The aim of this course is to provide an introduction to the overall drug discovery process. The main focus of the course will be on medicinal chemistry, synthesis and catalysis, as they relate to large-scale production of pharmaceutical agents. However, other aspects of drug discovery, including structural research (e.g. NMR, X-ray), biochemistry, drug metabolism and bioavailability will also be included.

  Terms: This course is not scheduled for the 2022-2023 academic year.

  Instructors: There are no professors associated with this course for the 2022-2023 academic year.

  • Fall

  • Prerequisite(s): CHEM 302 and one of BIOL 200 or CHEM 332, or permission of instructor.

• PHAR 503 Drug Discovery and Development 1 (3 credits)

  Offered by: Pharmacology and Therapeutics (Faculty of Science)

  Overview

  Pharmacology and Therapeutics : Chemistry, mechanisms of action, and steps in drug discovery and development.

  Terms: Fall 2022

  Instructors: Munter, Lisa; Sharif Naeini, Reza; Meerovitch, Karen; Mooser, Vincent (Fall)

  • Fall

  • Prerequisites: PHAR 301 or PHAR 303; or permission of instructor

At least 3 credits from the following:

• BIOC 600 Advanced Strategies in Genetics and Genomics (3 credits)

  Offered by: Biochemistry (Faculty of Medicine and Health Sciences)

  Administered by: Graduate Studies

  Overview

  Biochemistry : Advanced technologies and methods in genomics research, presented by experts actively pursuing the experimental approaches discussed.

  Terms: Fall 2022

  Instructors: Duchaine, Thomas; Montpetit, Alexandre; Dejgaard, Kurt; Dostie, Josee; Giguere, Vincent; Najafabadi, Hamed; Yamanaka, Yojiro; Huang, Sidong; Watson, Ian; Kazak, Lawrence (Fall)

  • Enrolment limited to 15 graduate students.

  • Prerequisite: BIOC 454 or equivalent

  • Restriction: Must take part in the Biochemistry graduate program

• BIOC 603 Genomics and Gene Expression (3 credits)

  Offered by: Biochemistry (Faculty of Medicine and Health Sciences)

  Administered by: Graduate Studies

  Overview

  Biochemistry : Examination of recent developments in analysis of eukaryotic cell genomes and control of gene expression during differentiation and growth control. Molecular genetics; genomics and the bioinformatics of analysis of genomic and functional-genomic data; mechanisms and signal-transduction pathways for regulation of gene expression; applications to human disease with a strong emphasis on cancer.

  Terms: Fall 2022

  Instructors: McCaffrey, Luke; Muller, William Joseph; Siegel, Peter; Huang, Sidong; Walsh, Logan; Kazak, Lawrence; Pastor, William (Fall)

  • Fall

  • Prerequisites: BIOC 454 and permission of instructor.

• BIOC 604 Macromolecular Structure (3 credits)

  Offered by: Biochemistry (Faculty of Medicine and Health Sciences)

  Administered by: Graduate Studies

  Overview

  Biochemistry : X-Ray crystallography, NMR spectroscopy, Electron Microscopy. Theory and methods used to determine macromolecular structures will be covered. Several practical sessions with hands-on experience for students are included.

  Terms: This course is not scheduled for the 2022-2023 academic year.

  Instructors: There are no professors associated with this course for the 2022-2023 academic year.

  • Offered in the Winter term, in even alternate years.

• BIOC 605 Protein Biology and Proteomics (3 credits)

  Offered by: Biochemistry (Faculty of Medicine and Health Sciences)

  Administered by: Graduate Studies

  Overview

  Biochemistry : Examination of recent developments in protein biology and proteomics analysis. Proteomics, modeling and biophysical approaches to characterize the functional interactions of biological macromolecules; applications to biological problems. Lectures and in-class discussions are supplemented by practical training in proteomics.

  Terms: Winter 2023

  Instructors: Corbeil, Christopher; Schmeing, Thomas Martin; Dejgaard, Kurt; Thomas, David; Hancock, Mark; Munter, Lisa (Winter)

  • Winter

  • Prerequisite: BIOC 450 or equivalent, or permission of instructor.

• BIOC 670 Biochemistry of Lipoproteins (3 credits)

  Offered by: Biochemistry (Faculty of Medicine and Health Sciences)

  Administered by: Graduate Studies

  Overview

  Biochemistry : Structure, function and metabolism of lipids and lipoproteins as they relate to lipid storage diseases, obesity, diabetes and heart disease.

  Terms: This course is not scheduled for the 2022-2023 academic year.

  Instructors: There are no professors associated with this course for the 2022-2023 academic year.

  • Prerequisite: BIOC 311 or permission of instructor

  • Restrictions: Open to graduate students only with permission of instructor.

  • Winter

• EXMD 615 Essentials of Glycobiology (3 credits)

  Offered by: Medicine (Faculty of Medicine and Health Sciences)

  Administered by: Graduate Studies

  Overview

  Experimental Medicine : Examination of the structure, function, and biosynthesis of glycoproteins, glycolipids and glycosaminoglycans, and the biological role of complex carbohydrates. Lectins, methods for elucidating carbohydrate structure, glycomics, and human diseases due to disorders of glycan synthesis.

  Terms: Winter 2023

  Instructors: Gilfix, Brian (Winter)

  • Winter

• EXMD 635D1 Experimental/Clinical Oncology (3 credits)

  Offered by: Medicine (Faculty of Medicine and Health Sciences)

  Administered by: Graduate Studies

  Overview

  Experimental Medicine : The course will deal, on a site by site basis, with the incidence of cancer, present treatment, treatment outcome, underlying causes, current research and directions for development of new treatments. Chemotherapy, surgery, radiation therapy and nutrition as therapy and treatment of cancer will be included.

  Terms: Fall 2022

  Instructors: Nepveu, Alain; Teodoro, Jose Guerreiro; Zogopoulos, George; Tanguay, Simon; Gregorieff, Alexander; Deblois, Genevieve; Fuks, Abraham; Shenouda, George; Sebag, Michael; Fiset, Pierre (Fall)

  • Prerequisite: Students must request permission from the instructor.

  • Students must register for both EXMD 635D1 and EXMD 635D2

  • No credit will be given for this course unless both EXMD 635D1 and EXMD 635D2 are successfully completed in consecutive terms

  • Previous solid knowledge in biochemistry and molecular biology required. Students will be required to write a long essay and give an oral presentation.

• EXMD 635D2 Experimental/Clinical Oncology (3 credits)

  Offered by: Medicine (Faculty of Medicine and Health Sciences)

  Administered by: Graduate Studies

  Overview

  Experimental Medicine : See EXMD 635D1 for course description.

  Terms: Winter 2023

  Instructors: Nepveu, Alain; Teodoro, Jose Guerreiro; Kassouf, Wassim; Zogopoulos, George; Johnson, Nathalie; Tanguay, Simon; Gregorieff, Alexander; Deblois, Genevieve; Fuks, Abraham; Laneuville, Pierre (Winter)

  • Prerequisite: EXMD 635D1 and permission from the instructor.

  • Students must register for both EXMD 635D1 and EXMD 635D2

  • No credit will be given for this course unless both EXMD 635D1 and EXMD 635D2 are successfully completed in consecutive terms

  • Previous solid knowledge in biochemistry and molecular biology required. Students will be required to write a long essay and give an oral presentation.

Plus additional credits to a total of at least 9 complementary course credits from the following list:

• CHEM 522 Stereochemistry (3 credits)

  Offered by: Chemistry (Faculty of Science)

  Overview

  Chemistry : Stereoisomers