Molecular Engineering of Scaffolds using Lasers for Osteogenesis and Angiogenesis

Summary

The project will investigate the growth of osteoblast and endothelial cells in in vitro model on a given bone scaffold and investigate the light-induced cell induction and conduction for osteogenesis and angiogenesis.

The biophysical aspect of the interaction of lasers in the cell culture and corresponding metabolic changes were characterized. The impact of laser power and induced changes (toxicity, cell damage, cell proliferation) will be analysed. The research, if time permits, maybe continued by using the human stem cells for light-induced cell differentiation for angiogenesis and osteogenesis. Industry support and training may be offered as well.

The project will offer the opportunity to work closely with a team of Engineering, Orthopaedic/Trauma Surgeon, and Stem Cell Biologist for exploring a new area of research for bone tissue engineering. You will learn:

1. Bone Scaffold engineering
2. Biophotonic interaction of Cells for induction and conduction (Osteoblast and Endothelial cells)
3. Apply the techniques developed in step b for osteoblast and endothelial cell growth in a tissue scaffold for future trials in animals.

Applicants to research degree programmes should normally have at least a first class or an upper second class British Bachelors Honours degree (or equivalent) in an appropriate discipline. The criteria for entry for some research degrees may be higher, for example, several faculties, also require a Masters degree. Applicants are advised to check with the relevant School prior to making an application. Applicants who are uncertain about the requirements for a particular research degree are advised to contact the School or Graduate School prior to making an application.

The minimum English language entry requirement for research postgraduate research study is an IELTS of 6.0 overall with at least 5.5 in each component (reading, writing, listening and speaking) or equivalent. The test must be dated within two years of the start date of the course in order to be valid. Some schools and faculties have a higher requirement.