Pharmacology of ion channels in human genetic disorders

Summary

The School of Biomedical Sciences invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2024/25.

We especially welcome applications that connect to the School's core research areas, which include Membrane Biology, Pharmacology, and Neuroscience.

We are studying the properties of human ion channels, primarily potassium channels, that have altered properties caused by genetic disorders. The PhD research project will explore the use of pharmacological agents in reversing the functional effects of inherited mutations that result in amino acid substitutions in the protein. For example, the use of inhibitors to supress an overactive ion channel in either a cellular or animal model of the disorder. These could form the basis of a stratified treatment.

Within our laboratory, we use functional techniques, including patch clamp electrophysiology and cellular fluorescence, to measure ion channel activity and the effects of mutations and pharmacological agents. We also work with structural biologists and medicinal and computational chemists to identify novel ion channel modulators. We also work with colleagues with expertise in animal models of human genetic disorders, as a means for preclinical testing of potential therapeutics.

Some of our recent research in this area has been published in iScience.

Applicants to research degree programmes should normally have at least a first class or an upper second class British Bachelors Honours degree (or equivalent) in an appropriate discipline. The criteria for entry for some research degrees may be higher, for example, several faculties, also require a Masters degree. Applicants are advised to check with the relevant School prior to making an application. Applicants who are uncertain about the requirements for a particular research degree are advised to contact the School or Graduate School prior to making an application.

The minimum English language entry requirement for research postgraduate research study is an IELTS of 6.0 overall with at least 5.5 in each component (reading, writing, listening and speaking) or equivalent. The test must be dated within two years of the start date of the course in order to be valid. Some schools and faculties have a higher requirement.