Seeing inside the brain of Alzheimer’s disease by cryoET

Summary

The aim of this PhD project is to determine the in situ 3D molecular structures associated with AD to understand disease mechanisms and molecular pathways that can lead to the rational design of a mechanism-based therapy. To this end, we have developed methods combining mouse genetics, post-mortem brain and cryo-electron microscopy (cryoEM).

See new story here: https://www.alzforum.org/news/research-news/amyloid-jungle-plaque-fibrils-mesh-all-manner-vesicles-membranes

The methods used will include: i) Electron tomography and computational image processing. ii) experiments with mouse models of Alzheimer’s disease, post-mortem AD brain iii) Biochemical and genetic labelling. Applicants from all backgrounds, including physical, chemical and biological sciences, are encouraged to apply. Some experience with programming (e.g. Python, Matlab or similar) will be highly advantageous.

This project will generate information-rich molecular structures of the mammalian brain that are expected to provide new insights into disease mechanisms. Thus, the student undertaking this research will receive an interdisciplinary training at the cutting edge of structural biology, neuroscience, and dementia research.

Applicants to research degree programmes should normally have at least a first class or an upper second class British Bachelors Honours degree (or equivalent) in an appropriate discipline. The criteria for entry for some research degrees may be higher, for example, several faculties, also require a Masters degree. Applicants are advised to check with the relevant School prior to making an application. Applicants who are uncertain about the requirements for a particular research degree are advised to contact the School or Graduate School prior to making an application.

The minimum English language entry requirement for research postgraduate research study is an IELTS of 6.0 overall with at least 5.5 in each component (reading, writing, listening and speaking) or equivalent. The test must be dated within two years of the start date of the course in order to be valid. Some schools and faculties have a higher requirement.