Filming photosynthesis: using computer simulations and fluorescence experiments to assess the dynamics of light-harvesting membranes from plants

Summary

Understanding the molecular basis of photosynthesis can support the development of improved crops and novel solar nanotechnologies. Plant proteins called Light-Harvesting (LH) complexes absorb sunlight and channel this energy to Photosystem (PS) proteins where that energy is transduced into a chemical form. These LH proteins are some of the most abundant membrane proteins on Earth, found in high numbers in the chloroplasts of all green plants. We know the structures of many of the proteins within this system, however, we do not understand how the proteins move in real time and how they interact with each other at the atomistic scale.

Computational methodologies, such as Molecular Dynamics (MD) simulations, allow us to follow the motion of such proteins over time in the membrane environment in which they function. In this project, we will use an interdisciplinary approach that combines MD simulations and fluorescence experiments such as spectroscopy and microscopy to: (1) quantify the effect of the lipid molecules on the function of LH and PS proteins, (2) to assess the interactions between multiple proteins and their clustering together. This research will lead to improved understanding of the biomolecules crucial for solar energy capture in photosynthesis and could have impact on plant science and sustainability.

We welcome applications from students with a background or interest biochemistry, chemistry or physics, or related fields. Applicants should be interested to learn about computational biophysics and experimental spectroscopy. We strongly encourage applications from candidates of diverse backgrounds, including those from underrepresented groups in STEM. Our research group is committed to providing a supportive and inclusive environment for all students. We are also committed to providing accommodations for students with disabilities. Please contact us to discuss any specific needs.

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