Ultra-fast Structural Dynamics in Biomimetic Cell Membranes

Summary

Living cells have adapted different mechanisms to proliferate and maintain their stability. Among those, motions of molecules in cell membranes play an important role. Those motions and movements include phospholipids rotation, its redistribution within a monolayer or exchange within bilayers. We know that these phenomena occur in broad time intervals, i.e., ranging from nanosecond to several minutes. Yet, how ultra-fast femtosecond motions support the cell cycle and control their functions like mechanical stability, membrane transport and signalling to be discovered.

This PhD project aims to unveil membranes dynamics with femtosecond time-resolution and capture images of single molecule of membrane in the act. The methodology will include developing microfluidics for synthesis of asymmetric biomimetic membranes and its applications for serial imaging by in X-ray and free electron laser scattering. The project will shed light onto how complex membranes evolved in stability and functions against more primitive ones.

Applicants to research degree programmes should normally have at least a first class or an upper second class British Bachelors Honours degree (or equivalent) in an appropriate discipline. The criteria for entry for some research degrees may be higher, for example, several faculties, also require a Masters degree. Applicants are advised to check with the relevant School prior to making an application. Applicants who are uncertain about the requirements for a particular research degree are advised to contact the School or Graduate School prior to making an application.

The minimum English language entry requirement for research postgraduate research study is an IELTS of 6.5 overall with at least 6.0 in each component (reading, writing, listening and speaking) or equivalent. The test must be dated within two years of the start date of the course in order to be valid.